United manager Michael Carrick has made three changes to the starting lineup, with Fernandes, Lisandro Martinez and Matheus Cunha all returning to the XI.
Kobbie Mainoo is also back in the matchday squad after missing United’s last four games through injury, but the midfielder starts on the bench alongside Mason Mount, Youri Tielemans and Ayden Heaven.
Meanwhile, Chelsea have handed Brazilian winger Estevao his first Premier League start of the season as manager Xabi Alonso makes four changes to the side that began Wednesday’s EFL Cup defeat to Liverpool.
Estevao is joined in the starting lineup by defenders Levi Colwill and Marco Palestra, while Cole Palmer returns after serving a suspension.
Malo Gusto and Danny Welbeck have been named among the substitutes, while Maxence Lacroix misses out with a hamstring injury. Jordan Henderson is also a surprise omission from the squad.
Chelsea starting XI: Penders; Acheampong, Fofana, Colwill, Palestra; Caicedo, Lavia; Estevao, Palmer, Neto; Rogers.
Substitutes: Sharman-Lowe, Barco, Welbeck, Emegha, Quenda, Gusto, Chavarria, Nicoll-Jazuli, Subuloye.
Manchester United starting XI: Lammens; Yoro, Maguire, Martinez, Dalot; Santos, Baleba; Amad, Fernandes, Cunha; Mbeumo.
Substitutes: Darlow, Mazraoui, De Ligt, Mount, Zirkzee, Tielemans, Heaven, Lacey, Mainoo.
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